Biochem/physiol Actions
Reversible: no
Product does not compete with ATP.
Primary TargetPKC
Cell permeable: yes
General description
A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.
A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain. Also available as a 10 mM solution in EtOH (Cat. No. 508225).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Gundimeda, U., et al. 1996. J. Biol. Chem. 271, 13504.Ye, Q. and Bodell, W.J. 1996. Carcinogenesis 17, 1747.Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol. 21, 985.Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health 4, 364.
Packaging
5 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
This product has met the following criteria to qualify for the following awards: