Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetPKC

Cell permeable: yes

General description

A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.

A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain. Also available as a 10 mM solution in EtOH (Cat. No. 508225).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Gundimeda, U., et al. 1996. J. Biol. Chem. 271, 13504.Ye, Q. and Bodell, W.J. 1996. Carcinogenesis 17, 1747.Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol. 21, 985.Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health 4, 364.

Packaging

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)